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体液免疫反应——宫颈癌患者:淋巴细胞毒性抗体(作者译)

[Humoral immune response--cervical cancer patients: lymphocytotoxic antibodies (author's transl)].

作者信息

Koenig U D, Müller N

出版信息

Arch Gynakol. 1978 Oct 18;225(4):267-74. doi: 10.1007/BF02570570.

Abstract

Sera of 120 cervical cancer patients as well as that of 116 healthy control persons were screened for lymphocytotoxic antibodies using microlymphocytotoxic tests variated in temperature and incubation time. In 76 of 120 cancer-sera (63.3%) lymphocytotoxic antibodies could be detected in comparison with 26 sera of 116 controls (22.4%); p less than 0.0005. With the differentiation into the stages of the disease the highest percentage of lymphocytotoxic antibodies was found in patients with stage 0 of cervical cancer. The presence of lymphocytotoxic antibodies in sera of cervical cancer patients suggest the possibility that this disease is an allotransplant as well as expression of an autoimmune process.

摘要

采用温度和孵育时间不同的微量淋巴细胞毒性试验,对120例宫颈癌患者的血清以及116例健康对照者的血清进行淋巴细胞毒性抗体筛查。120例癌症患者血清中有76例(63.3%)可检测到淋巴细胞毒性抗体,而116例对照者血清中有26例(22.4%)可检测到;p<0.0005。根据疾病分期进行区分,发现宫颈癌0期患者中淋巴细胞毒性抗体的比例最高。宫颈癌患者血清中存在淋巴细胞毒性抗体提示,该疾病可能是同种异体移植以及自身免疫过程的表现。

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