Katz S M, Brodsky I, Kahn S B
Arch Pathol Lab Med. 1979 May;103(5):261-4.
During the Legionnaires' disease epidemic that occurred in Philadelphia in 1976, we performed a transbronchial lung biopsy on a patient who suffered from Legionnaires' disease that was confirmed by serology. The biopsy was performed in an attempt to detect a causal agent for the patient's pneumonia at a time when the cause of the epidemic was a mystery. We detected pleomorphic microbial structures that were both intracellular and extracellular in location. By electron microscopy, they ranged in size from 350 nm to 2.5 mu. Some displayed cell walls and fine cytoplasmic granules that resembled ribosomes. Our findings illustrate the appearance of the Legionnaires' disease agent in acutely infected, antibiotic-treated human lung obtained from biopsy specimens.
在1976年发生于费城的军团病疫情期间，我们对一名经血清学确诊患有军团病的患者进行了经支气管肺活检。当时疫情的病因仍是个谜，此次活检旨在试图找出该患者肺炎的病原体。我们检测到多形性微生物结构，它们位于细胞内和细胞外。通过电子显微镜观察，其大小范围为350纳米至2.5微米。一些显示出细胞壁和类似核糖体的精细细胞质颗粒。我们的研究结果展示了从活检标本获取的急性感染且接受过抗生素治疗的人肺中军团病病原体的形态。
