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妓女中的人类白细胞抗原与性传播疾病

HLA and sexually transmitted diseases in prostitutes.

作者信息

Chan S H, Tan T, Kamarudin A, Wee G B, Rajan V S

出版信息

Br J Vener Dis. 1979 Jun;55(3):207-10. doi: 10.1136/sti.55.3.207.

DOI:10.1136/sti.55.3.207
PMID:582426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1045631/
Abstract

The HLA profile of 148 unrelated, Chinese prostitutes (56 with repeated gonococcal infection, 31 with syphilis, 31 with gonorrhoea and syphilis, and 30 with no evidence of infection) was compared with that of 238 unrelated, healthy, Chinese control subjects. The joint occurrence of AW19 B17 was observed in 25.8% of prostitutes with double infections compared with 6.7% of control subjects, while that of A11 B15, on the other hand, was associated with a resistance to syphilis and gonorrhoea. The latter profile was observed in 46.7% of prostitutes in business for more than two years who were resistant to disease, in 30% of prostitutes with an overall disease resistance, in 13.4% of control subjects, and in only 3.2% of prostitutes with combined syphilis and gonorrhoea. Because of the statistical uncertainty when multiple variables are being analysed these studies should be repeated in other groups of prostitutes of the same and different ethnic origins.

摘要

将148名无亲缘关系的中国妓女(56名有复发性淋球菌感染,31名有梅毒,31名有淋病和梅毒,30名无感染迹象)的HLA谱与238名无亲缘关系的健康中国对照者的HLA谱进行了比较。在双重感染的妓女中,AW19 B17的联合出现率为25.8%,而对照者为6.7%;另一方面,A11 B15与对梅毒和淋病的抗性有关。在从业两年以上且抗病的妓女中,后一种谱型的出现率为46.7%,在总体抗病的妓女中为30%,在对照者中为13.4%,而在合并梅毒和淋病的妓女中仅为3.2%。由于在分析多个变量时存在统计不确定性,这些研究应在相同和不同种族来源的其他妓女群体中重复进行。

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本文引用的文献

1
Genetic mapping of Ir locus in man: linkage to second locus of HL-A.人类Ir基因座的遗传定位:与HL - A第二基因座的连锁关系。
Science. 1974 Jun 21;184(4143):1301-3. doi: 10.1126/science.184.4143.1301.
2
In vitro immune responsiveness to vaccinia virus and HLA.针对痘苗病毒和人类白细胞抗原的体外免疫反应性
N Engl J Med. 1977 Sep 29;297(13):692-6. doi: 10.1056/NEJM197709292971303.