人类Ir基因座的遗传定位：与HL - A第二基因座的连锁关系。
Genetic mapping of Ir locus in man: linkage to second locus of HL-A.
作者信息
Blumenthal M N, Amos D B, Noreen H
出版信息
Science. 1974 Jun 21;184(4143):1301-3. doi: 10.1126/science.184.4143.1301.
PMID:4833283
Abstract
Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.
摘要
对一个跨越三代的57名家庭成员进行了抗原E、豚草皮肤敏感性和HL - A抗原的研究。在这个家族中，单倍型HL - A 2 - 12与抗原E皮肤超敏反应之间存在显著关联（F = 0.22至0.26）。图谱顺序为HL - A的第一个位点、HL - A的第二个位点和IrE。这些决定簇被认为是连锁群HL - 1的一部分。
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