Loeb J N, Howell R R, Tomkins G M
Science. 1965 Sep 3;149(3688):1093-5. doi: 10.1126/science.149.3688.1093.
After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.
单次注射放射性乳清酸并“追踪”非放射性前体后，大鼠肝脏中核糖体RNA的比活性以对数形式下降，下降速率对应的半衰期约为5天。就蛋白质合成的控制而言，讨论了这一结果可能的意义。
