Harvey R J
J Bacteriol. 1965 Nov;90(5):1330-6. doi: 10.1128/jb.90.5.1330-1336.1965.
Harvey, R. J. (The Dairy Research Institute, Palmerston North, New Zealand). Damage to Streptococcus lactis resulting from growth at low pH. J. Bacteriol. 90:1330-1336. 1965.-Growth of Streptococcus lactis below pH 5.0 results in damage to the cells. A period of growth below pH 5.0 is required before this damage is expressed, and a period of growth above pH 5.0 is required to correct the damage. Part of the damage consists of a reduction in the specific activities of a number of enzymes. At the same time, the differential rate of total protein synthesis is unchanged. During recovery from growth at low pH, the enzymes subject to damage are formed at a differential rate which is higher than normal until the normal specific activities are restored. The growth rate characteristic of the new pH is then resumed. The results are consistent with either of two mechanisms of damage. Growth at low pH could result either in direct inactivation of a number of enzymes, or in loss of control of the differential rates of synthesis of individual enzymes.
哈维，R. J.（新西兰北帕默斯顿乳业研究所）。低pH值下生长对乳酸链球菌造成的损伤。《细菌学杂志》90:1330 - 1336。1965年。——乳酸链球菌在pH值低于5.0的环境中生长会导致细胞受损。在这种损伤表现出来之前，需要在pH值低于5.0的环境中生长一段时间，而要修复这种损伤则需要在pH值高于5.0的环境中生长一段时间。部分损伤表现为多种酶的比活性降低。与此同时，总蛋白质合成的差异速率没有变化。在从低pH值生长环境中恢复的过程中，受损的酶以高于正常水平的差异速率合成，直到恢复正常的比活性。然后恢复新pH值下特有的生长速率。这些结果与两种损伤机制中的任何一种都相符。在低pH值下生长可能直接导致多种酶失活，或者导致对单个酶合成差异速率的控制丧失。
