支气管癌与吸烟者的单核细胞趋化作用
Monocyte chemotaxis in bronchial carcinoma and cigarette smokers.
作者信息
Kay A B, McVie J G
出版信息
Br J Cancer. 1977 Oct;36(4):461-6. doi: 10.1038/bjc.1977.215.
Abstract
Chemotaxis of blood monocytes was measured in 31 patients with bronchial carcinoma and 19 cigarette smokers. Thirteen patients with metastatic bronchial carcinoma had significantly less (P less than 0.005) chemotactic response than matched controls. Those with disease confined to the chest, or with recurrent or operable bronchial carcinoma, had no significant depression of monocyte chemotaxis. There was also no significant difference in monocyte chemotaxis between cigarette smokers and matched controls. These results support the concept that in human cancer there is a defect in monocyte chemotaxis, but in bronchial carcinoma significant depression was only apparent in those with advanced disease.
摘要
对31例支气管癌患者和19名吸烟者的血液单核细胞趋化性进行了检测。13例转移性支气管癌患者的趋化反应明显低于配对对照组（P<0.005）。病变局限于胸部、或患有复发性或可手术支气管癌的患者，其单核细胞趋化性无明显降低。吸烟者与配对对照组之间的单核细胞趋化性也无显著差异。这些结果支持了人类癌症中存在单核细胞趋化性缺陷的观点，但在支气管癌中，只有晚期患者的单核细胞趋化性才明显降低。
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