正常和绝经后骨质疏松症女性的血浆雄烯二酮和雌酮水平。
Plasma androstenedione and oestrone levels in normal and osteoporotic postmenopausal women.
作者信息
Marshall D H, Crilly R G, Nordin B E
出版信息
Br Med J. 1977 Nov 5;2(6096):1177-9. doi: 10.1136/bmj.2.6096.1177.
Abstract
Plasma androstenedione and oestrone concentrations were measured in 72 postmenopasual women. The women included some who had undergone oophorectomy, some with osteoporosis, and normal controls; they were matched for years since menopause. Both hormone concentrations were significantly reduced in the women with osteoporosis. The women who had undergone oophorectomy had hormone concentrations intermediate between the normal and osteoporotic values. Oestrogen deficiency secondary to low androstenedione levels is a major risk factor in postmenopausal osteoporosis, and may be caused by failure of ovarian stromal androgen secretion or some abnormality in the pituitary-adrenal axis.
摘要
对72名绝经后女性的血浆雄烯二酮和雌酮浓度进行了测量。这些女性包括一些接受过卵巢切除术的、一些患有骨质疏松症的以及正常对照组；根据绝经后的年限进行了匹配。骨质疏松症女性的两种激素浓度均显著降低。接受过卵巢切除术的女性激素浓度介于正常和骨质疏松症数值之间。雄烯二酮水平低导致的雌激素缺乏是绝经后骨质疏松症的主要危险因素，可能是由于卵巢基质雄激素分泌失败或垂体-肾上腺轴的某些异常所致。
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