贾第虫病空肠上皮中淋巴细胞浸润的定量分析。
Quantification of the lymphocytic infiltrate in jejunal epithelium in giardiasis.
作者信息
Wright S G, Tomkins A M
出版信息
Clin Exp Immunol. 1977 Sep;29(3):408-12.
The intraepithelial lymphocytes of the jejunal mucosa from patients with giardiasis and from control patients were counted in coded serial sections. Patients with giardiasis and normal intestinal absorption and control patients who had lived and travelled in tropical areas had similar counts, which were higher than those reported for controls from temperate areas. Where giardiasis was accompanied by malabsorption of one substance the mean count was significantly higher than that of controls (P less than 0.02). In those patients with giardiasis and malabsorption of two or three substances the mean count was significantly higher than that of controls (P less than 0.02) and that of patients with giardiasis and normal absorption (P less than 0.05). After treatment, intraepithelial lymphocyte counts declined consistently in patients with malabsorption. An association between raised intraepithelial lymphocyte counts and malabsorption is indicated. The possible significance of this finding is discussed.
对贾第虫病患者和对照患者空肠黏膜上皮内淋巴细胞进行编码连续切片计数。贾第虫病患者且肠道吸收正常者，以及曾在热带地区生活和旅行的对照患者，其淋巴细胞计数相似，高于温带地区对照者的报告值。若贾第虫病伴有一种物质吸收不良，平均计数显著高于对照者（P<0.02）。在那些患有贾第虫病且两种或三种物质吸收不良的患者中，平均计数显著高于对照者（P<0.02）以及贾第虫病且吸收正常的患者（P<0.05）。治疗后，吸收不良患者的上皮内淋巴细胞计数持续下降。提示上皮内淋巴细胞计数升高与吸收不良之间存在关联。并讨论了这一发现的可能意义。
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