Heimann G, Gladtke E
Eur J Clin Pharmacol. 1977 Dec 2;12(4):305-10. doi: 10.1007/BF00607431.
In 14 neonates 1-4 weeks old, 30 babies aged 1-12 months, and 7 infants of 1-5 years of age, the serum levels of phenobarbital were determined by a gas chromatographic micro-method after intravenous injection of phenobarbital 5-10 mg per kg body weight. It was possible to calculate the pharmacokinetic parameters using a two compartment open model. The distribution volumes within the individual age groups and the rate constants k12 and k21 showed no significant differences, but the elimination half-life was significantly longer in neonates (118.6+/-16.1h) than in babies (62.9+/-5.2h) or infants (68.5+/-3.2h).
对14名1至4周龄的新生儿、30名1至12个月大的婴儿以及7名1至5岁的幼儿，静脉注射每公斤体重5至10毫克苯巴比妥后，采用气相色谱微量法测定血清苯巴比妥水平。使用二室开放模型可以计算药代动力学参数。各年龄组内的分布容积以及速率常数k12和k21无显著差异，但新生儿的消除半衰期（118.6±16.1小时）明显长于婴儿（62.9±5.2小时）或幼儿（68.5±3.2小时）。
