Onishi S, Ohki Y, Nishimura Y, Itoh S, Isobe K, Hosoe A, Yamamoto T, Yamakawa T
Dev Pharmacol Ther. 1984;7(3):153-9. doi: 10.1159/000457158.
The present study was performed to determine whether serum levels of phenobarbital were representative of their concentrations in the brains obtained from 11 autopsied patients, including premature and full-term babies, infants and children. Estimation of phenobarbital concentrations in plasma and organs was performed by high-pressure liquid chromatography. Brain phenobarbital concentrations correlated well with serum levels (r = 0.82, p less than 0.01, n = 11), giving a regression line with a slope of 0.75. It can be concluded that estimating the serum phenobarbital concentration during clinical pediatric practice gives a good indication of the brain concentration.
本研究旨在确定11例尸检患者（包括早产儿、足月儿、婴儿和儿童）血清中苯巴比妥水平是否代表其大脑中的浓度。采用高压液相色谱法测定血浆和器官中苯巴比妥的浓度。脑苯巴比妥浓度与血清水平相关性良好（r = 0.82，p < 0.01，n = 11），回归直线斜率为0.75。可以得出结论，在临床儿科实践中估算血清苯巴比妥浓度能很好地反映大脑中的浓度。
