Althaus D, Keller H U, Hess M W, Cottier H
Int Arch Allergy Appl Immunol. 1980;61(3):321-8. doi: 10.1159/000232454.
Neutrophils from patients with acute bacterial infections show a marked decrease in random as well as directional locomotion in vitro. The further analysis of the data suggests that defective directional locomotion is due to impaired locomotion and not to impaired chemotaxis. The defect disappeared almost completely with clinical recovery. There was no direct correlation between impaired directional neutrophil locomotion and the proportion of band forms in the neutrophil population. Plasma obtained from patients with acute bacterial infections showed no 'spontaneous' chemotactic activity and immune complex-induced cytotaxin formation was normal in vitro. Neutrophils from 2 patients with viral pneumonia showed normal locomotion.
急性细菌感染患者的中性粒细胞在体外随机运动以及定向运动均显著减少。对数据的进一步分析表明，定向运动缺陷是由于运动能力受损而非趋化性受损所致。随着临床康复，该缺陷几乎完全消失。中性粒细胞定向运动受损与中性粒细胞群体中杆状核细胞比例之间无直接关联。急性细菌感染患者的血浆未显示“自发”趋化活性，且体外免疫复合物诱导的细胞趋化素形成正常。两名病毒性肺炎患者的中性粒细胞运动正常。
