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New antitumor antibiotics, OS-4742 A1, A2, B1 and B2 produced by a strain of Streptomyces.

作者信息

Omura S, Tanaka H, Oiwa R, Awaya J, Masuma R, Tanaka K

出版信息

J Antibiot (Tokyo). 1977 Nov;30(11):908-16. doi: 10.7164/antibiotics.30.908.

DOI:10.7164/antibiotics.30.908
PMID:591459
Abstract

New antibiotics, OS-4742 A1, A2, B1 and B2, were isolated from the culture broth of the strain OS-4742, which was designated as Streptomyces matensis subsp. vineus. These compounds have anthracycline chromophores and sugar moieties, but do not contain nitrogen. They possess antimicrobial activities against Gram-positive bacteria and antitumor activities against S-180 solid tumor on mice.

摘要

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