一种由链霉菌菌株产生的新型抗生素，塞托米星。

A new antibiotic, setomimycin, produced by a strain of Streptomyces.

作者信息

Omura S, Tanaka H, Iwai Y, Nishigaki K, Awaya J, Takahashi Y, Masuma R

出版信息

J Antibiot (Tokyo). 1978 Nov;31(11):1091-8. doi: 10.7164/antibiotics.31.1091.

DOI:10.7164/antibiotics.31.1091

Abstract

A new antibiotic, setomimycin, was isolated from the culture broth of strain AM-2947, which was identified as Streptomyces pseudovenezuelae. The compound is a weakly acidic substance, and has UV-absorption at 228, 268 and 422 nm and a molecular formula of C34H28O9 (MW 580). It is active against Gram-positive bacteria including Mycobacteria, and has antitumor activity against Sarcoma-180 solid tumor in mice.

摘要

一种新的抗生素，司托米星，是从菌株AM - 2947的培养液中分离出来的，该菌株被鉴定为委内瑞拉链霉菌。该化合物是一种弱酸性物质，在228、268和422nm处有紫外吸收，分子式为C34H28O9（分子量580）。它对包括分枝杆菌在内的革兰氏阳性菌有活性，并且对小鼠肉瘤 - 180实体瘤具有抗肿瘤活性。