Weissmann G, Sessa G, Bernheimer A W
Science. 1966 Nov 11;154(3750):772-4. doi: 10.1126/science.154.3750.772.
Staphylococcal alpha-toxin induces the release of previously sequestered anions or glucose from artificial phospholipid spherules, an effect abolished by specific antitoxin. Alphatoxin resembles streptolysin S in releasing anions or glucose from spherules prepared without cholesterol, and can be distinguished from the membrane-active polyene amphotericin B, which preferentially disrupts spherules containing cholesterol. It may affect biological structures by a similiar interaction with membrane phospholipids.
葡萄球菌α毒素可诱导先前被隔离的阴离子或葡萄糖从人工磷脂小球中释放出来，这种效应可被特异性抗毒素消除。α毒素在从不含胆固醇的小球中释放阴离子或葡萄糖方面类似于链球菌溶血素S，并且可以与膜活性多烯两性霉素B区分开来，两性霉素B优先破坏含有胆固醇的小球。它可能通过与膜磷脂的类似相互作用来影响生物结构。
