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趋化性研究。十二。补体缺乏血清中多形核白细胞趋化活性的产生。

Studies on chemotaxis. XII. Generation of chemotactic activity for polymorphonuclear leucocytes in sera with complement dificiencies.

作者信息

Stecher V J, Sorkin E

出版信息

Immunology. 1969 Feb;16(2):231-9.

PMID:5769979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409584/
Abstract

The significance of the C′ system for chemotaxis of rabbit PMNs was studied . C′6-deficient rabbit sera and C′5-deficient mouse sera were compared with normal rabbit and mouse sera for their ability to generate chemotactic factors in the presence of antigen—antibody complexes and endotoxins. No difference could be detected between these C′-deficient and normal sera. Full chemotactic activity was observed even when a rabbit anti-C′6 serum was incubated with an antigen—antibody complex. These results are incompatible with C′ (5, 6, 7) being the chemotactic factor in serum for polymorphonuclear leucocytes.

摘要

研究了补体系统对兔多形核白细胞趋化作用的意义。将C′6缺陷兔血清和C′5缺陷小鼠血清与正常兔和小鼠血清相比较，观察它们在存在抗原-抗体复合物和内毒素的情况下产生趋化因子的能力。未检测到这些补体缺陷血清与正常血清之间存在差异。甚至当兔抗C′6血清与抗原-抗体复合物一起温育时，也观察到了完全的趋化活性。这些结果与补体（5, 6, 7）作为血清中多形核白细胞趋化因子的观点不一致。

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Immunology. 1969 Feb;16(2):231-9.
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引用本文的文献

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Infect Immun. 1970 Jun;1(6):521-5. doi: 10.1128/iai.1.6.521-525.1970.
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J Clin Invest. 1974 Feb;53(2):544-53. doi: 10.1172/JCI107588.
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本文引用的文献

1
A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.多形核白细胞和补体在肾毒性肾炎中的作用
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THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO.血清补体在体外白细胞趋化性中的作用
J Exp Med. 1965 Aug 1;122(2):327-46. doi: 10.1084/jem.122.2.327.
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DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT.抗原MUB1的分布、遗传特性及其与溶血补体的关系
J Exp Med. 1964 Nov 1;120(5):897-924. doi: 10.1084/jem.120.5.897.
4
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.抗体与抗原混合物对多形核白细胞的趋化作用。
J Exp Med. 1962 Mar 1;115(3):453-66. doi: 10.1084/jem.115.3.453.
5
Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro.体外多形核白细胞对A组链球菌吞噬作用的研究。
J Exp Med. 1960 Mar 1;111(3):309-22. doi: 10.1084/jem.111.3.309.
6
Deficiency of the sixth component of complement in rabbits with an inherited complement defect.患有遗传性补体缺陷的兔子体内补体第六成分的缺乏。
J Exp Med. 1966 Oct 1;124(4):773-85. doi: 10.1084/jem.124.4.773.
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Nephrotoxic serum nephritis in mice with a genetic deficiency in complement.补体基因缺陷小鼠的肾毒性血清肾炎
J Immunol. 1968 Jan;100(1):34-8.
8
A molecular concept of immune cytolysis.免疫细胞溶解的分子概念。
Arch Pathol. 1966 Sep;82(3):205-17.
9
Studies on chemotaxis. VI. Specific chemotaxis in rabbit polymorphonuclear leucocytes and mononuclear cells.趋化性研究。VI. 兔多形核白细胞和单核细胞中的特异性趋化性。
Int Arch Allergy Appl Immunol. 1967;31(6):575-86.
10
Chemotaxis of leucocytes.白细胞的趋化性。
Experientia. 1968 Jul 15;24(7):641-52. doi: 10.1007/BF02138287.