趋化性研究。十二。补体缺乏血清中多形核白细胞趋化活性的产生。
Studies on chemotaxis. XII. Generation of chemotactic activity for polymorphonuclear leucocytes in sera with complement dificiencies.
作者信息
Stecher V J, Sorkin E
出版信息
Immunology. 1969 Feb;16(2):231-9.
Abstract
The significance of the C′ system for chemotaxis of rabbit PMNs was studied . C′6-deficient rabbit sera and C′5-deficient mouse sera were compared with normal rabbit and mouse sera for their ability to generate chemotactic factors in the presence of antigen—antibody complexes and endotoxins. No difference could be detected between these C′-deficient and normal sera. Full chemotactic activity was observed even when a rabbit anti-C′6 serum was incubated with an antigen—antibody complex. These results are incompatible with C′ (5, 6, 7) being the chemotactic factor in serum for polymorphonuclear leucocytes.
摘要
研究了补体系统对兔多形核白细胞趋化作用的意义。将C′6缺陷兔血清和C′5缺陷小鼠血清与正常兔和小鼠血清相比较，观察它们在存在抗原-抗体复合物和内毒素的情况下产生趋化因子的能力。未检测到这些补体缺陷血清与正常血清之间存在差异。甚至当兔抗C′6血清与抗原-抗体复合物一起温育时，也观察到了完全的趋化活性。这些结果与补体（5, 6, 7）作为血清中多形核白细胞趋化因子的观点不一致。
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