镁离子对血清杀菌反应的逆转作用。
Reversal of the bactericidal reaction of serum by magnesium ion.
作者信息
Muschel L H, Jackson J E
出版信息
J Bacteriol. 1966 Apr;91(4):1399-402. doi: 10.1128/jb.91.4.1399-1402.1966.
Abstract
Muschel, Louis H. (University of Minnesota, Minneapolis), and Jean E. Jackson. Reversal of the bactericidal reaction of serum by magnesium ion. J. Bacteriol. 91:1399-1402. 1966.-Magnesium ion was found to reverse the bactericidal action of the antibody-complement system. Concentrations of 0.03 to 0.11 m MgSO(4) or MgCl(2) were effective, provided that the reaction of the antibody-complement system did not proceed longer than 50 min. Salts of other monovalent and divalent cations, the polyamine, spermine, and several anticomplementary substances were inactive in reversing the serum bactericidal reaction. Thus, the bactericidal reaction of serum may be bacteriostatic under certain conditions, and this finding is compatible with the persistence of infection in certain diseases despite high levels of antibody.
摘要
马斯赫尔，路易斯·H.（明尼苏达大学，明尼阿波利斯），以及琼·E.杰克逊。镁离子对血清杀菌反应的逆转作用。《细菌学杂志》91:1399 - 1402。1966年。——发现镁离子可逆转抗体 - 补体系统的杀菌作用。只要抗体 - 补体系统的反应进行时间不超过50分钟，0.03至0.11摩尔/升的硫酸镁或氯化镁浓度是有效的。其他单价和二价阳离子的盐、多胺、精胺以及几种抗补体物质在逆转血清杀菌反应方面无活性。因此，血清的杀菌反应在某些条件下可能是抑菌的，这一发现与某些疾病中尽管抗体水平很高但感染仍持续存在的情况相符。
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