来自绳状青霉的一种抗病毒物质。V. 海伦宁对干扰素的诱导作用
An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine.
作者信息
Rytel M W, Shope R E, Kilbourne E D
出版信息
J Exp Med. 1966 Apr 1;123(4):577-84. doi: 10.1084/jem.123.4.577.
Abstract
Helenine, a substance obtained from broth cultures of Penicillium funiculosum and known to exert a protective effect in vivo in experimental animals against several unrelated viruses, has been shown to elicit the formation in cell cultures and in intact mice of an inhibitor of viral plaque formation. Because the biological and chemical characteristics of the viral inhibitor induced by helenine are similar to those of interferon, it is suggested that the antiviral effect of helenine may be mediated through the formation of interferon.
摘要
海伦宁是一种从绳状青霉肉汤培养物中获得的物质，已知它在实验动物体内对几种不相关的病毒具有保护作用，现已证明它能在细胞培养物和完整小鼠体内引发病毒空斑形成抑制剂的形成。由于海伦宁诱导产生的病毒抑制剂的生物学和化学特性与干扰素相似，因此有人提出海伦宁的抗病毒作用可能是通过干扰素的形成介导的。
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