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相似文献

1
Stereochemical model for proflavin intercalation in A-DNA.原黄素嵌入A-DNA的立体化学模型。
Nucleic Acids Res. 1977 Nov;4(11):3855-61. doi: 10.1093/nar/4.11.3855.
2
Molecular mechanical studies of proflavine and acridine orange intercalation.硫酸原黄素和吖啶橙嵌入的分子力学研究。
Nucleic Acids Res. 1981 Mar 25;9(6):1483-97. doi: 10.1093/nar/9.6.1483.
3
The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.药物-脱氧核苷磷酸复合物的结构；与RNA和DNA片段形成的嵌入复合物的一般构象行为。
Nucleic Acids Res. 1980 Jan 11;8(1):85-97. doi: 10.1093/nar/8.1.85.
4
Conformation and dynamics of drug-DNA intercalation.药物 - DNA 嵌入的构象与动力学
J Biomol Struct Dyn. 1992 Aug;10(1):97-139. doi: 10.1080/07391102.1992.10508633.
5
X-ray-structure of a cytidylyl-3',5'-adenosine-proflavine complex: a self-paired parallel-chain double helical dimer with an intercalated acridine dye.胞苷酰-3',5'-腺苷-硫酸普罗黄素复合物的X射线结构：一种带有嵌入吖啶染料的自配对平行链双螺旋二聚体。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1852-6. doi: 10.1073/pnas.77.4.1852.
6
Visualization of planar drug intercalations in B-DNA.B型DNA中平面药物插入的可视化。
Nucleic Acids Res. 1975 Oct;2(10):1701-17. doi: 10.1093/nar/2.10.1701.
7
Effects of proflavin and photoactivated proflavin on the template function of single-stranded DNA.硫酸原黄素及光活化硫酸原黄素对单链DNA模板功能的影响。
J Mol Biol. 1990 Jan 5;211(1):63-74. doi: 10.1016/0022-2836(90)90011-A.
8
A molecular model for proflavine-DNA intercalation.原黄素-DNA嵌入的分子模型。
Nucleic Acids Res. 1988 Sep 26;16(18):8999-9016. doi: 10.1093/nar/16.18.8999.
9
Crystallographic studies of drug-nucleic acid interactions: proflavine intercalation between the non-complementary base-pairs of cytidilyl-3',5'-adenosine.药物与核酸相互作用的晶体学研究：硫酸普罗黄素嵌入胞苷-3',5'-腺苷的非互补碱基对之间。
J Mol Biol. 1980 Sep 25;142(3):331-61. doi: 10.1016/0022-2836(80)90276-4.
10
A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis.体外移码诱变过程中序列特异性原黄素 - DNA 相互作用的结构模型。
J Biomol Struct Dyn. 1992 Oct;10(2):317-31. doi: 10.1080/07391102.1992.10508650.

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Fluorescein as a topical fluorescent contrast agent for quantitative microendoscopic inspection of colorectal epithelium.荧光素作为一种局部荧光造影剂用于大肠上皮的定量显微内镜检查。
Biomed Opt Express. 2017 Mar 24;8(4):2324-2338. doi: 10.1364/BOE.8.002324. eCollection 2017 Apr 1.
2
In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett's-related neoplasia in a single-endoscopic insertion.单内镜插入时 Barrett 相关肿瘤的体内白光和对比增强活染料荧光成像。
J Biomed Opt. 2016 Aug 1;21(8):86004. doi: 10.1117/1.JBO.21.8.086004.
3
Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology.硫酸普罗黄素作为即时护理细胞学的荧光造影剂。
PLoS One. 2015 May 11;10(5):e0125598. doi: 10.1371/journal.pone.0125598. eCollection 2015.
4
The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.药物-脱氧核苷磷酸复合物的结构；与RNA和DNA片段形成的嵌入复合物的一般构象行为。
Nucleic Acids Res. 1980 Jan 11;8(1):85-97. doi: 10.1093/nar/8.1.85.
5
Molecular mechanical studies of proflavine and acridine orange intercalation.硫酸原黄素和吖啶橙嵌入的分子力学研究。
Nucleic Acids Res. 1981 Mar 25;9(6):1483-97. doi: 10.1093/nar/9.6.1483.
6
Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.核酸结合药物。第十三部分。药物 - 核酸模型系统中的分子运动：原黄素 - 二核苷晶体结构的热运动分析。
Nucleic Acids Res. 1985 Aug 12;13(15):5671-84. doi: 10.1093/nar/13.15.5671.
7
Molecular mechanical simulations on double intercalation of 9-amino acridine into d(CGCGCGC) X d(GCGCGCG): analysis of the physical basis for the neighbor-exclusion principle.9-氨基吖啶插入d(CGCGCGC)×d(GCGCGCG)双链的分子力学模拟：邻位排斥原理的物理基础分析
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5735-9. doi: 10.1073/pnas.84.16.5735.
8
A molecular model for proflavine-DNA intercalation.原黄素-DNA嵌入的分子模型。
Nucleic Acids Res. 1988 Sep 26;16(18):8999-9016. doi: 10.1093/nar/16.18.8999.
9
The influence of terminal 3', 5' phosphates on conformations of dApdA.3'、5' 末端磷酸对 dApdA 构象的影响。
Nucleic Acids Res. 1979;6(6):2165-78. doi: 10.1093/nar/6.6.2165.
10
Sugar pucker geometries at the intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution.碘化丙啶嵌入溶液中微型RNA和DNA双链体插入位点处的糖环构象。
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2553-7. doi: 10.1073/pnas.75.6.2553.

本文引用的文献

1
The structure of the DNA-acridine complex.DNA-吖啶复合物的结构。
Proc Natl Acad Sci U S A. 1963 Jan 15;49(1):94-102. doi: 10.1073/pnas.49.1.94.
2
Structural considerations in the interaction of DNA and acridines.DNA与吖啶相互作用中的结构考量
J Mol Biol. 1961 Feb;3:18-30. doi: 10.1016/s0022-2836(61)80004-1.
3
Optimised parameters for A-DNA and B-DNA.A-DNA和B-DNA的优化参数。
Biochem Biophys Res Commun. 1972 Jun 28;47(6):1504-9. doi: 10.1016/0006-291X(72)90243-4.
4
Interactions of aromatic residues of proteins with nucleic acids. I. Proton magnetic resonance studies of the binding of tryptophan-containing peptides to poly(adenylic acid) and deoxyribonucleic acid.蛋白质芳香族残基与核酸的相互作用。I. 含色氨酸肽与聚腺苷酸和脱氧核糖核酸结合的质子磁共振研究。
Biochemistry. 1974 Feb 12;13(4):714-23. doi: 10.1021/bi00701a013.
5
The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients.溴化乙锭对DNA螺旋的解旋程度。I. 在碱性氯化铯密度梯度中对扭曲的PM2 DNA分子进行滴定。
J Mol Biol. 1974 Nov 15;89(4):783-801. doi: 10.1016/0022-2836(74)90053-9.
6
Supercoiling of polyoma virus DNA measured by its interaction with ethidium bromide.通过多瘤病毒DNA与溴化乙锭的相互作用来测定其超螺旋结构。
J Mol Biol. 1967 Apr 14;25(1):23-30. doi: 10.1016/0022-2836(67)90276-8.
7
Drugs which affect the structure and function of DNA.影响DNA结构与功能的药物。
Nature. 1968 Sep 28;219(5161):1320-5. doi: 10.1038/2191320a0.
8
Stereochemistry of actinomycin binding to DNA. I. Refinement and further structural details of the actinomycin-deoxyguanosine crystalline complex.放线菌素与DNA结合的立体化学。I. 放线菌素-脱氧鸟苷晶体复合物的结构优化及更多细节
J Mol Biol. 1972 Jul 14;68(1):1-20. doi: 10.1016/0022-2836(72)90258-6.
9
Studies of the binding of actinomycin and related compounds to DNA.放线菌素及相关化合物与DNA结合的研究。
J Mol Biol. 1968 Jul 28;35(2):251-90. doi: 10.1016/s0022-2836(68)80024-5.
10
Visualization of planar drug intercalations in B-DNA.B型DNA中平面药物插入的可视化。
Nucleic Acids Res. 1975 Oct;2(10):1701-17. doi: 10.1093/nar/2.10.1701.

原黄素嵌入A-DNA的立体化学模型。

Stereochemical model for proflavin intercalation in A-DNA.

作者信息

Alden C J, Arnott S

出版信息

Nucleic Acids Res. 1977 Nov;4(11):3855-61. doi: 10.1093/nar/4.11.3855.

DOI:10.1093/nar/4.11.3855
PMID:593890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC343205/
Abstract

Linked-atom molecular modelling was employed to determine the steric and torsional requirements for intercalation of proflavine into a double-stranded region of DNA compatible with adjacent regions of cohelical A-DNA. The optimum intercalation conformation is characterized by the dihedral angles xi and psi becoming trans, with all sugars retaining the characteristics C3'-endo pucker. This extended conformation results in virtually no helical unwinding, suggesting it may be an appropriate model for an intercalative intermediary in mutagenesis by virtue of its similarity to standard helical DNA.

摘要

采用连接原子分子模型来确定原黄素嵌入与共螺旋A-DNA相邻区域兼容的双链DNA区域的空间和扭转要求。最佳嵌入构象的特征是二面角ξ和ψ变为反式，所有糖都保持C3'-内型褶皱的特征。这种伸展构象几乎不会导致螺旋解旋，这表明由于其与标准螺旋DNA相似，它可能是诱变中嵌入中间体的合适模型。