原黄素嵌入A-DNA的立体化学模型。
Stereochemical model for proflavin intercalation in A-DNA.
作者信息
Alden C J, Arnott S
出版信息
Nucleic Acids Res. 1977 Nov;4(11):3855-61. doi: 10.1093/nar/4.11.3855.
Abstract
Linked-atom molecular modelling was employed to determine the steric and torsional requirements for intercalation of proflavine into a double-stranded region of DNA compatible with adjacent regions of cohelical A-DNA. The optimum intercalation conformation is characterized by the dihedral angles xi and psi becoming trans, with all sugars retaining the characteristics C3'-endo pucker. This extended conformation results in virtually no helical unwinding, suggesting it may be an appropriate model for an intercalative intermediary in mutagenesis by virtue of its similarity to standard helical DNA.
摘要
采用连接原子分子模型来确定原黄素嵌入与共螺旋A-DNA相邻区域兼容的双链DNA区域的空间和扭转要求。最佳嵌入构象的特征是二面角ξ和ψ变为反式，所有糖都保持C3'-内型褶皱的特征。这种伸展构象几乎不会导致螺旋解旋，这表明由于其与标准螺旋DNA相似，它可能是诱变中嵌入中间体的合适模型。
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