Azzopardi J G, Lehner T
J Clin Pathol. 1966 Nov;19(6):539-48. doi: 10.1136/jcp.19.6.539.
Among 8,758 necropsies there are 93 cases of systemic amyloidosis. Of these, 14 are associated with malignancy: seven with myelomatosis or malignant lymphoma, and seven with carcinoma. The incidence of amyloidosis in myelomatosis is at least 10%. Attention is drawn to the presence of amyloid in the tubular casts of ;myeloma kidney'. In Hodgkin's disease the incidence is about 4% but it may be higher in patients receiving chemotherapy. In lymphosarcoma it is of the order of a fraction of 1% but in macroglobulinaemia, essential or associated with malignant lymphoma, the incidence is considerably higher. Systemic amyloid is found in one in 375 of patients with carcinoma and in only a single patient among 1,500 ;control cases'. Renal carcinoma accounts for one-quarter of all carcinomas associated with systemic amyloid. The other carcinomas originate in a variety of organs. In myelomatosis, amyloid may be found in the tumour deposits. In Hodgkin's disease and in lymphosarcoma there appears to be greater amyloid deposition in neoplastic tissue than hitherto realized. The carcinomas provide a striking example of topographical association of amyloid and tumour, the two being closely related in six of seven cases.
在8758例尸检中，有93例系统性淀粉样变性。其中，14例与恶性肿瘤相关：7例与骨髓瘤或恶性淋巴瘤相关，7例与癌相关。骨髓瘤中淀粉样变性的发生率至少为10%。值得注意的是“骨髓瘤肾病”的肾小管管型中存在淀粉样物质。在霍奇金病中，发生率约为4%，但接受化疗的患者中可能更高。在淋巴肉瘤中，发生率约为千分之一，但在巨球蛋白血症（原发性或与恶性淋巴瘤相关）中，发生率则高得多。系统性淀粉样变性在375例癌症患者中出现1例，而在1500例“对照病例”中仅1例。肾癌占所有与系统性淀粉样变性相关癌症的四分之一。其他癌症起源于多种器官。在骨髓瘤中，淀粉样物质可在肿瘤沉积物中发现。在霍奇金病和淋巴肉瘤中，肿瘤组织中的淀粉样物质沉积似乎比以往认识的更多。癌提供了淀粉样物质与肿瘤在局部关联的显著例子，在7例中有6例两者密切相关。
