[切断腹腔神经和迷走神经对大鼠肝脏乳酸脱氢酶活性及同工酶组成的影响]
[Effect of sectioning the celiac and vagus nerves on the activity and isoenzymatic composition of rat liver lactate dehydrogenase].
作者信息
Shanygina K I, Parfernova N S
出版信息
Vopr Med Khim. 1977 Sep-Oct;23(5):650-2.
Total activity of lactate dehydrogenase (LDH) was increased in rat liver cytoplasm after dissection of nervus celiacus; the enzyme activity was, however, decreased after section of nervus vagus. As showen by polyacrylamide gel electrophoresis the alterations in the enzyme activity occurred mainly due to changes in the isoenzyme LDH5, prevailing in this liver fraction. Administration of insulin did not restore the LDH activity, decreased after vagotomy. The suggestion is corroborated that the regulatory effects of sympathetic and parasympathetic nervous systems on glycolysis are of oppositely directed character.
切断腹腔神经后，大鼠肝细胞质中乳酸脱氢酶（LDH）的总活性增加；然而，切断迷走神经后该酶活性降低。聚丙烯酰胺凝胶电泳显示，酶活性的改变主要是由于该肝部分中占主导的同工酶LDH5的变化所致。胰岛素给药并未恢复迷走神经切断后降低的LDH活性。这证实了交感神经系统和副交感神经系统对糖酵解的调节作用具有相反的方向。
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