Mitcheson H D, Hilgard P, McCraw A, Castro J E
Br J Cancer. 1980 Jan;41(1):117-22. doi: 10.1038/bjc.1980.13.
I.v. injection of Corynebacterium parvum (CP) into C57BL and BALB/c mice caused profound coagulation changes, featuring thrombocytopenia, decreased fibrinogen, increased fibrin/fibrinogen degradation products, and a concomitant microangiopathic haemolytic anaemia. These changes were greatest on the 9th day after CP, with recovery by Day 21. I.p. injection caused similar effects but s.c. injection was ineffective. Radiolabelled-platelet kinetics and distribution after i.v. CP indicated disseminated intravascular coagulation with rapid fibrinolysis; EACA treatment exacerbated the thrombosis. The coagulopathy correlated with hepatosplenomegaly, and both were dose dependent. Splenectomy did not effect the coagulopathy, but indomethacin totally abrogated the changes, suggesting that prostaglandin biosynthesis is involved in the pathogenesis.
向C57BL和BALB/c小鼠静脉注射短小棒状杆菌（CP）会引起严重的凝血变化，其特征为血小板减少、纤维蛋白原降低、纤维蛋白/纤维蛋白原降解产物增加，并伴有微血管病性溶血性贫血。这些变化在注射CP后第9天最为明显，到第21天恢复。腹腔注射产生类似效果，但皮下注射无效。静脉注射CP后放射性标记血小板的动力学和分布表明存在弥散性血管内凝血并伴有快速纤维蛋白溶解；氨基己酸治疗会加重血栓形成。凝血病与肝脾肿大相关，且两者均呈剂量依赖性。脾切除术对凝血病无影响，但吲哚美辛可完全消除这些变化，提示前列腺素生物合成参与了发病机制。
