重症肌无力中的乙酰胆碱酯酶活性与月经缓解情况
Acetylcholinesterase activity and menstrual remissions in myasthenia gravis.
作者信息
Vijayan N, Vijayan V K, Dreyfus P M
出版信息
J Neurol Neurosurg Psychiatry. 1977 Nov;40(11):1060-5. doi: 10.1136/jnnp.40.11.1060.
Menstrually related temporary remissions of myasthenic symptoms are reported to occur in 25 to 50% of female patients. Even though this has been attributed to hormonal changes associated with the menstrual cycle the underlying mechanism of this hormonal influence has remained elusive. The present study demonstrated a cyclical variation in the activity of red cell acetylcholinesterase (EC 3.1.1.7) enzyme (AChE) with a marked reduction at the time of menstrual remission of symptoms of myasthenia. These cyclical changes were abolished by thymectomy. It appears, therefore, that menstrual remission in myasthenia is at least partly due to hormone-induced changes in AChE activity. This process seems to be under the control of the thymus gland.
据报道，25%至50%的女性重症肌无力患者会出现与月经相关的肌无力症状暂时缓解。尽管这被归因于与月经周期相关的激素变化，但这种激素影响的潜在机制仍然难以捉摸。本研究表明，红细胞乙酰胆碱酯酶（EC 3.1.1.7）（AChE）的活性存在周期性变化，在重症肌无力症状月经缓解期时活性显著降低。胸腺切除术后，这些周期性变化消失。因此，重症肌无力的月经缓解似乎至少部分是由于激素引起的AChE活性变化。这个过程似乎受胸腺控制。
Zotero 插件