脑脊液中烯醇化酶及其他酶的水平作为病理变化指标。
Levels of enolase and other enzymes in the cerebrospinal fluid as indices of pathological change.
作者信息
Royds J A, Timperley W R, Taylor C B
出版信息
J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1129-35. doi: 10.1136/jnnp.44.12.1129.
Abstract
The activities of enolase, aldolase, pyruvate kinase, lactate dehydrogenase and creatine phosphokinase were measured in cerebrospinal fluid of 121 patients presenting with a range of disorders of the central nervous system. The results from 41 patients undergoing myelography were used as controls. An assessment was made of the relative merits of these five enzymes as markers of brain damage with special reference to brain tumours. Enolase was the most sensitive marker of pathological change and was the only enzyme raised in the CSF of patients with low grade astrocytomas.
摘要
对121例患有一系列中枢神经系统疾病的患者的脑脊液进行了烯醇化酶、醛缩酶、丙酮酸激酶、乳酸脱氢酶和肌酸磷酸激酶活性的检测。41例接受脊髓造影的患者的检测结果用作对照。特别针对脑肿瘤，评估了这五种酶作为脑损伤标志物的相对优点。烯醇化酶是病理变化最敏感的标志物，并且是低度星形细胞瘤患者脑脊液中唯一升高的酶。
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