Guilleminault C, Tilkian A G, Dement W C
Electroencephalogr Clin Neurophysiol. 1976 Oct;41(4):367-78. doi: 10.1016/0013-4694(76)90099-7.
A sleep apnea syndrome has been diagnosed in eight children (age range 5-14). Before undertaking therapeutic trials, sleep and respiration were extensively studied. Sleep and respiration were again analyzed 3 months after tonsillectomy and adenoidectomy (6 cases) or tracheostomy with insertion of valve (2 cases). Sleep induced apneic apisodes in these children who had normal respiration during wakefulness. Three types of apnea (central, upper airway, and mixed) were recorded in each case. The minimum number of apneas recorded during a single night was 75; the maximum was 816. Polygraphic monitoring demonstrated greatly disturbed sleep. Sleep changes were quantitative as well as qualitative. REM sleep percent was decreased, but stages 3 and 4 NREM sleep were also impaired. A relationship between stages 3-4 NREM sleep and respiration was noted: stages 3-4 sleep disappeared when apneic episodes were numerous; no apnea was recorded during stage 4 sleep. Follow-up nocturnal recordings of two tracheostomized children with valve open, then closed, confirmed this "stage 4/no apnea" relationship. Apneas were also noted to induce marked sinus arrhythmia during sleep.
已确诊8名儿童(年龄5至14岁)患有睡眠呼吸暂停综合征。在进行治疗试验之前,对睡眠和呼吸进行了广泛研究。在扁桃体切除术和腺样体切除术(6例)或气管切开并插入瓣膜(2例)3个月后,再次分析睡眠和呼吸情况。这些在清醒时呼吸正常的儿童在睡眠中出现呼吸暂停发作。每种情况均记录到三种类型的呼吸暂停(中枢性、上气道性和混合性)。单个晚上记录到的呼吸暂停最少次数为75次;最多为816次。多导睡眠监测显示睡眠受到严重干扰。睡眠变化既有数量上的,也有质量上的。快速眼动睡眠百分比降低,但非快速眼动睡眠的3期和4期也受到损害。注意到非快速眼动睡眠3至4期与呼吸之间的关系:当呼吸暂停发作频繁时,3至4期睡眠消失;在4期睡眠期间未记录到呼吸暂停。两名气管切开并带有瓣膜的儿童在瓣膜打开和关闭时的夜间随访记录证实了这种“4期睡眠/无呼吸暂停”的关系。还注意到呼吸暂停在睡眠期间会诱发明显的窦性心律失常。