Johansson S, Wahlqvist L
Acta Pathol Microbiol Scand A. 1977 Nov;85(6):768-74. doi: 10.1111/j.1699-0463.1977.tb03892.x.
Forty-two patients with a bladder tumour and 4 patients with a ureteral tumour and a history of abuse of phenacetin-containing analgesics were studied. The sex ratio was 1:1, and the mean age 63 years. The estimated amount of ingested phenacetin was 7.1 kg, the estimated mean exposure time 21 years, and the estimated mean induction time 30 years. Renal papillary necrosis and impaired renal function were found in 34 patients. A history of recurrent urinary tract infection was found in 80 per cent of the patients, suggesting that the combination of phenacetin-abuse and chronic inflammation might be responsible for the localization of the tumours to the bladder. The majority of the bladder tumours were of low grade (1 and 2); muscular invasion was seldom found and metastases were rare. The patients were followed for 1.5-13 years. Twenty-six patients died; the mean survival time was 46 months. Uremia due to analgesic nephropathy was the main cause of death in 14 patients and contributed to death in another 7 patients. Three of the patients with ureteral tumours had received radiological treatment against the pelvic region, 15-20 years prior to the diagnosis of the ureteral tumour.
对42例膀胱肿瘤患者以及4例输尿管肿瘤患者进行了研究，这些患者均有服用含非那西丁止痛剂的滥用史。男女比例为1:1，平均年龄63岁。非那西丁的估计摄入量为7.1千克，估计平均接触时间为21年，估计平均诱导时间为30年。34例患者出现肾乳头坏死和肾功能损害。80%的患者有复发性尿路感染病史，这表明非那西丁滥用与慢性炎症相结合可能是肿瘤定位于膀胱的原因。大多数膀胱肿瘤为低级别（1级和2级）；很少发现肌肉浸润，转移也很少见。对患者进行了1.5至13年的随访。26例患者死亡；平均生存时间为46个月。14例患者因止痛剂肾病导致的尿毒症是主要死因，另有7例患者的死亡与之有关。3例输尿管肿瘤患者在诊断输尿管肿瘤前15至20年曾接受过盆腔区域的放射治疗。
