Fernandez-Madrid F, Noonan S, Riddle J
J Anat. 1981 Mar;132(Pt 2):157-66.
The "spindle-shaped" or "fusiform" bodies of fibroblasts are membrane-bound collagen fibrils. These cellular organelles, also described in the literature as rods or cigars, can be induced massively in chick embryo fibroblasts by treatment with colchicine in vinblastine. These alkaloids also induce massively the presence of non-striated fibrils, segment long-spacing (SLS) and fibrous long-spacing (FLS) crystallites in cytoplasmic vacuoles. The intracellular fibrillar structures described within the cytoplasmic vacuoles suggest the occurrence of tropocollagen interconversions, indication that under the experimental conditions used in this work some procollagen is processed intracellularly. Our findings may represent the first step of autophagocytosis of collagenous products when the secretory process is blocked. It is possible that these agents, by blocking secretion, magnify a normal process, and that under normal conditions a population of procollagen molecules may be processed intracellularly, thus contributing to the process of fibrillogenesis.
成纤维细胞的“纺锤形”或“梭形”小体是膜结合的胶原纤维。这些细胞器在文献中也被描述为杆状或雪茄状，用秋水仙碱和长春碱处理鸡胚成纤维细胞可大量诱导其产生。这些生物碱还能大量诱导细胞质液泡中出现无横纹纤维、段长间距（SLS）和纤维长间距（FLS）微晶。细胞质液泡中描述的细胞内纤维状结构表明原胶原蛋白发生了相互转化，这表明在本研究使用的实验条件下，一些前胶原蛋白在细胞内进行了加工。我们的发现可能代表了分泌过程受阻时胶原产物自噬作用的第一步。有可能这些试剂通过阻断分泌放大了一个正常过程，并且在正常条件下，一部分前胶原蛋白分子可能在细胞内进行加工，从而促进纤维形成过程。
