慢性淋巴细胞白血病——伴有单克隆IgA的高分化淋巴细胞淋巴瘤：循环淋巴细胞产生IgA
Chronic lymphocytic leukemia--well-differentiated lymphocytic lymphoma with monoclonal IgA:IgA production by circulating lymphocytes.
作者信息
Stein R S, Kozin F, Rothwell D
出版信息
Am J Hematol. 1977;3:187-92. doi: 10.1002/ajh.2830030210.
PMID:602936
Abstract
A patient is described in whom morphologic features of well-differentiated lymphocytic lymphoma (WDL) or chronic lymphocytic leukemia (CLL) and immunologic features of multiple myeloma were present. Studies of isolated peripheral blood lymphocytes demonstrated de novo synthesis of IgA K, the same paraprotein that was identified in the serum. Predominant IgA synthesis by peripheral lymphocytes has not been previously shown in either WDL or CLL.
摘要
本文描述了一名患者，其具有高分化淋巴细胞淋巴瘤（WDL）或慢性淋巴细胞白血病（CLL）的形态学特征以及多发性骨髓瘤的免疫学特征。对分离的外周血淋巴细胞的研究表明，其可从头合成IgA κ，这与血清中鉴定出的同一副蛋白相同。外周淋巴细胞以IgA合成为主的情况在WDL或CLL中此前均未被发现。
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