Mosher D B, Parrish J A, Fitzpatrick T B
Br J Dermatol. 1977 Dec;97(6):669-79. doi: 10.1111/j.1365-2133.1977.tb14275.x.
Of 18 severely afffected vitiligo patients who used 20% monobenzylether of hydroquinone (MBEH, Benoquin) as a depigmenting agent, 8 achieved complete depigmentation after 10 months or more of use and 3 dramatic but no complete hypopigmentation. The 3 patients with no results did not use MBEH for more than 4 months. Complications were frequent particularly among those who did well, but only 1 case of contact dermatitis limited therapy. All patients who depigmented fully were very pleased with their results. As depigmentation induced by MBEH is generally irreversible, MBEH use must be reserved for induction of complete depigmentation of severely affected vitiligo patients who cannot or do not choose to repigment and who can accept the permanence of never tanning. The history, histology and mechanism of MBEH depigmentation are discussed.
在18名重度白癜风患者中，使用20%对苯二酚单苄醚（MBEH，白癜净）作为脱色剂，8名患者在使用10个月或更长时间后实现了完全脱色，3名患者出现显著但未完全的色素减退。3名无效果的患者使用MBEH的时间未超过4个月。并发症很常见，尤其是在效果良好的患者中，但仅有1例接触性皮炎限制了治疗。所有完全脱色的患者对结果都非常满意。由于MBEH诱导的脱色通常是不可逆的，MBEH的使用必须限于诱导重度白癜风患者完全脱色，这些患者无法或不选择重新色素沉着，并且能够接受永远不会晒黑的永久性。本文讨论了MBEH脱色的病史、组织学和机制。
