抗体应答的遗传控制。II. 决定簇特异性控制特异性的进一步分析，以及CBA和C57小鼠对（H，G）-A--L应答的遗传分析。
Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice.
作者信息
McDevitt H O, Sela M
出版信息
J Exp Med. 1967 Nov 1;126(5):969-78. doi: 10.1084/jem.126.5.969.
Abstract
CBA and C57 mice were tested for their ability to make an immune response to a related series of branched, multichain synthetic polypeptide antigens in which the antigenic determinants on the amino termini of the branched side chains were systematically varied. Neither strain responded to the polyglutamic acid determinant. Both strains responded well and equally to the poly(phenylalanine, glutamic acid) determinants. CBA mice responded poorly, and C57 mice responded well to two different antigens bearing poly(tyrosine, glutamic acid) determinants. CBA mice responded well, and CS7 mice responded poorly to two different antigens bearing poly(histidine, glutamic acid) determinants. The genetic control of the immune response to (H,G)-A--L appears to be dominant and polygenic, as it has been shown to be for (T,G)-A--L. The related antigens used in this study show extensive cross-reactions with antisera against other members of the related series.
摘要
对CBA和C57小鼠进行了测试，以检测它们对一系列相关的分支多链合成多肽抗原产生免疫反应的能力，这些抗原中分支侧链氨基末端的抗原决定簇被系统地改变。两种品系对聚谷氨酸决定簇均无反应。两种品系对聚（苯丙氨酸，谷氨酸）决定簇反应良好且相同。CBA小鼠反应较差，而C57小鼠对带有聚（酪氨酸，谷氨酸）决定簇的两种不同抗原反应良好。CBA小鼠反应良好，而C57小鼠对带有聚（组氨酸，谷氨酸）决定簇的两种不同抗原反应较差。对（H，G）-A--L免疫反应的遗传控制似乎是显性和多基因的，正如对（T，G）-A--L所显示的那样。本研究中使用的相关抗原与针对相关系列其他成员的抗血清显示出广泛的交叉反应。
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Genetic control of the antibody response. II. Further analysis of the specificity of determinant-specific control, and genetic analysis of the response to (H,G)-A--L in CBA and C57 mice.抗体应答的遗传控制。II. 决定簇特异性控制特异性的进一步分析，以及CBA和C57小鼠对（H，G）-A--L应答的遗传分析。
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