Bakkeren J A, Sengers R C, Trijbels J M, Engels P H
Eur J Pediatr. 1977 Dec 30;127(1):41-7. doi: 10.1007/BF00465564.
A very unusual pattern of organic acid excretion was established in the urine of two premature newborns with severe respiratory distress and cerebral haemorrhages. By combined gas chromatography/mass spectrometry the following acids were identified: lactic acid, alpha-hydroxy-butyric acid, beta-hydroxy-butyric acid, alpha-hydroxy-isovaleric acid, and p-hydroxy-phenyllactic acid. Calculation of the concentration revealed an excessive excretion of lactic acid and also very high excretion of the other acids. A postmortem blood sample from one of the patients revealed a comparable pattern. The abnormal urinary organic acid excretion pattern was most probably caused by severe tissue hypoxia.
在两名患有严重呼吸窘迫和脑出血的早产新生儿尿液中，发现了一种非常不寻常的有机酸排泄模式。通过气相色谱/质谱联用技术，鉴定出了以下几种酸：乳酸、α-羟基丁酸、β-羟基丁酸、α-羟基异戊酸和对羟基苯乳酸。浓度计算显示，乳酸排泄过量，其他酸的排泄量也非常高。其中一名患者的尸检血样显示出类似的模式。异常的尿有机酸排泄模式很可能是由严重的组织缺氧引起的。
