一项关于人体对乙苯皮肤吸收情况的研究。
A study of the skin absorption of ethylbenzene in man.
作者信息
Dutkiewicz T, Tyras H
出版信息
Br J Ind Med. 1967 Oct;24(4):330-2. doi: 10.1136/oem.24.4.330.
Abstract
The absorption of ethylbenzene through the skin of the hand and the forearm in men was investigated experimentally. Both the absorption of liquid ethylbenzene and the absorption from aqueous solutions were studied. The rate of absorption of liquid ethylbenzene was 22 to 33 mg./cm./hr, and the rates from aqueous solutions were 118 and 215 μg./cm./hr from mean concentrations of 112 and 156 mg./litre. The mandelic acid excreted in urine was equivalent to about 4·6% of the absorbed dose—much less than after lung absorption. Urinary mandelic acid does not provide a reliable index of absorption when there is simultaneous skin and lung exposure.
摘要
对男性手部和前臂皮肤吸收乙苯的情况进行了实验研究。研究了液态乙苯的吸收以及从水溶液中的吸收情况。液态乙苯的吸收速率为22至33毫克/平方厘米/小时，平均浓度为112毫克/升和156毫克/升的水溶液的吸收速率分别为118微克/平方厘米/小时和215微克/平方厘米/小时。尿液中排出的扁桃酸约相当于吸收剂量的4.6%，远低于肺部吸收后的比例。当皮肤和肺部同时接触时，尿中扁桃酸不能提供可靠的吸收指标。
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