日本起源的HLA - D抗原（LD - Wa）及其与葡萄膜大脑炎综合征的关联。

HLA-D antigen of Japanese origin (LD-Wa) and its association with Vogt-Koyanagi-Harada syndrome.

作者信息

Yakura H, Wakisaka A, Aizawa M, Itakura K, Tagawa Y

出版信息

Tissue Antigens. 1976 Jul;8(1):35-42. doi: 10.1111/j.1399-0039.1976.tb00549.x.

DOI:10.1111/j.1399-0039.1976.tb00549.x

Abstract

One homozygous cell "Wa" for HLA-D alleles, associated with HLA-Bw22J (Japanese specific variant of HLA-Bw22), was found in a Japanese family. The HLA-D antigenic specificity defined by this cell has been tentatively named LD-Wa. Phenotype frequency of LD-Wa in the Japanese population was 0.16 (13/81). HLA-D typing for LD-Wa was performed in patients with the Vogt-Koyanagi-Harada syndrome (Harada's disease) with which Bw22J is strongly associated (15/35, 42.9%; corrected P less than 0.02). LD-Wa was presented in 22 of 33 patients (33.7%; P less than 0.0000003). The association of LD-Wa with Harada's disease was stronger than that of Bw22J, and this implies that there might be one of the disease susceptibility gene loci affecting the development of this disease more closely linked to an HLA-D gene locus than the HLA-B locus.

摘要

在一个日本家庭中发现了一个与HLA - Bw22J（HLA - Bw22的日本特异性变体）相关的HLA - D等位基因纯合细胞“Wa”。由该细胞定义的HLA - D抗原特异性暂定为LD - Wa。LD - Wa在日本人群中的表型频率为0.16（13/81）。对与Bw22J密切相关的Vogt - 小柳 - 原田综合征（原田病）患者进行了LD - Wa的HLA - D分型（15/35，42.9%；校正P小于0.02）。33例患者中有22例出现LD - Wa（33.7%；P小于0.0000003）。LD - Wa与原田病的关联比Bw22J更强，这意味着可能存在一个影响该疾病发展的疾病易感基因位点，它与HLA - D基因位点的连锁比HLA - B位点更紧密。