Leaper D J, Brennan S S, Simpson R A, Foster M E
J Hosp Infect. 1984 Dec;5 Suppl A:69-73. doi: 10.1016/0195-6701(84)90033-1.
The prolonged use of a hydrogel (polyacrylamide) dressing on circular 1 cm skin defects was tested in a rat experimental model. The rate of healing and changes in bacterial content following inoculation of 1 X 10(8) Staphylococcus aureus, Escherichia coli or Pseudomonas aeruginosa were measured. Wounds inoculated with Staph. aureus or E. coli prior to polyacrylamide occlusion did not have delayed wound contraction and healing and numbers of organisms were falling at 10 days. Wounds inoculated with Ps. aeruginosa showed a delay in healing with a large increase in organisms (greater than 1 X 10(10] after 10 days occlusion. Prolonged wound occlusion by hydrogel dressings may aid in healing by secondary intention but the presence or growth of pseudomonas indicates that frequent changes of dressings should be made.
在大鼠实验模型中测试了水凝胶（聚丙烯酰胺）敷料在直径1厘米的圆形皮肤缺损上的长期使用情况。测量了接种1×10⁸金黄色葡萄球菌、大肠杆菌或铜绿假单胞菌后的愈合速率和细菌含量变化。在聚丙烯酰胺封闭之前接种金黄色葡萄球菌或大肠杆菌的伤口没有延迟伤口收缩和愈合，并且在第10天时生物体数量下降。接种铜绿假单胞菌的伤口愈合延迟，生物体数量大幅增加（封闭10天后大于1×10¹⁰）。水凝胶敷料的长期伤口封闭可能有助于二期愈合，但铜绿假单胞菌的存在或生长表明应频繁更换敷料。
