Altered expression of different tubulin electrophoretic variants during human cortex development.

Two alpha and two beta tubulin subunits are synthesized in vitro by polyadenylated mRNAs isolated from fetal and adult human cortex. The relative levels of the mRNAs encoding the different subunits change dramatically during development. In the fetus, the mRNA for beta 1 tubulin is present at higher levels than that of the beta 2 electrophoretic variant. There are relatively high levels of the mRNAs encoding both alpha subunits. In the adult, the levels of the mRNAs encoding both the alpha subunits and the beta 1 subunit are decreased relative to those of the mRNAs encoding the beta 2 subunit. These results suggest that fetal and adult cortical cells have very different requirements for the different tubulin electrophoretic variants.