e抗原/e抗体的临床意义，特别提及肝脏中的核心抗原。

Clinical significance of e-antigen/anti-e, with special reference to HBc-antigen in the liver.

作者信息

Furuta S, Kiyosawa K, Nagata A, Koike Y, Sahara T, Furukawa K, Iijima Y, Yamamura S, Komatsu H, Kawahara K, Miura M, Gibo Y, Sodeyama K, Oda M, Tsuda F, Akahane Y, Mayumi M

出版信息

Gastroenterol Jpn. 1977;12(6):460-5. doi: 10.1007/BF02781338.

DOI:10.1007/BF02781338

PMID:608568

Abstract

e-antigen and anti-e were assayed in sera of asymptomatic HBs-Ag carriers and of patients with liver diseases. Thirteen out of 34 (38.2%) asymptomatic carriers were positive for e-antigen, which was in sharp contrast to the reports from USA and Europe. e-antigen was detected to a greater extent in patients with chronic active hepatitis, reversely anti-e in patients with chronic persistent hepatitis. However, e-antigen was found rarely in patients with cirrhosis and never in 23 cases with hepatoma positive for HBs-Ag. HBc-Ag in the liver was detected in 4 out of 8 e-antigen positive asymptomatic carriers and in 4 out of 5 patients with chronic liver diseases with e-antigen respectively, and moreover in 3 out of 14 anti-e positive cases, so that the presence of anti-e did not necessarily mean the negativity of HBc-Ag in the liver. Anti-HBc titer, however, was lower in anti-e positive sera than in e-antigen positive ones. This may implicate the decreased replication of HBV in cases with anti-e. These results emphasize that the investigation of e-antigen/anti-e is mandatory for the evaluation of the prognosis of asymptomatic carriers and of patients with chronic hepatitis.

摘要

对无症状乙肝表面抗原携带者和肝病患者的血清进行了e抗原和抗e检测。34名无症状携带者中有13名（38.2%）e抗原呈阳性，这与美国和欧洲的报告形成鲜明对比。慢性活动性肝炎患者中e抗原的检出率更高，而慢性持续性肝炎患者中抗e的检出率更高。然而，肝硬化患者中很少检测到e抗原，在23例乙肝表面抗原阳性的肝癌患者中则从未检测到。在8例e抗原阳性的无症状携带者中，有4例在肝脏中检测到乙肝核心抗原；在5例e抗原阳性的慢性肝病患者中，有4例也检测到了乙肝核心抗原；此外，在14例抗e阳性病例中有3例检测到了乙肝核心抗原，因此抗e的存在并不一定意味着肝脏中乙肝核心抗原呈阴性。然而，抗e阳性血清中的抗乙肝核心抗体滴度低于e抗原阳性血清。这可能意味着抗e情况下乙肝病毒复制减少。这些结果强调，对于评估无症状携带者和慢性肝炎患者的预后，e抗原/抗e检测是必不可少的。