血小板活化因子对豚鼠乳头肌的作用。
Effect of platelet activating factor on guinea-pig papillary muscle.
作者信息
Camussi G, Alloatti G, Montrucchio G, Meda M, Emanuelli G
出版信息
Experientia. 1984 Jul 15;40(7):697-9. doi: 10.1007/BF01949729.
PMID:6086382
Abstract
Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.
摘要
血小板活化因子（PAF）对豚鼠乳头肌产生双相效应：1. 短暂的正性肌力作用，之前伴有动作电位时程（APD）增加；2. 对心肌收缩力和动作电位时程有显著的负性作用。由于PAF最初增强了Ca++慢动作电位，随后又使其显著降低，提示PAF特异性干扰Ca++慢通道。
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