Kato K, Yamamoto K, Okuyama H, Kimura T
Infect Immun. 1984 Aug;45(2):325-31. doi: 10.1128/iai.45.2.325-331.1984.
Morphological and functional changes in lung macrophages from mice injected intravenously with Mycobacterium bovis BCG cell walls (CWs) were studied. In BCG CW high-responder mice (C57BL/6 [B6] strain), an increase in the size and the acid phosphatase activity of lung macrophages was observed. These lung macrophages showed greater microbicidal activity to M. bovis Ravenel and Listeria monocytogenes EGD, enhanced superoxide anion production index, and greater macrophage migration inhibition activity, as compared with lung macrophages from BCG CW low-responder mice (C3H/He strain), which were small in size and showed weak acid phosphatase activity, low antimicrobial activity, and low superoxide anion production index upon intravenous injection of the mice with BCG CW. These results indicated that lung macrophages from B6 mice injected with BCG CWs were morphologically and functionally activated, but not those from C3H mice.
研究了静脉注射牛分枝杆菌卡介苗细胞壁（CWs）的小鼠肺巨噬细胞的形态和功能变化。在卡介苗CW高反应性小鼠（C57BL/6 [B6] 品系）中，观察到肺巨噬细胞的大小和酸性磷酸酶活性增加。与卡介苗CW低反应性小鼠（C3H/He品系）的肺巨噬细胞相比，这些肺巨噬细胞对牛分枝杆菌Ravenel和单核细胞增生李斯特菌EGD表现出更强的杀菌活性，超氧阴离子产生指数增强，巨噬细胞迁移抑制活性更高。C3H/He品系小鼠静脉注射卡介苗CW后，其肺巨噬细胞体积小，酸性磷酸酶活性弱，抗菌活性低，超氧阴离子产生指数低。这些结果表明，注射卡介苗CW的B6小鼠的肺巨噬细胞在形态和功能上被激活，而C3H小鼠的肺巨噬细胞则未被激活。
