Kato K, Nakane A, Minagawa T, Kasai N, Yamamoto K, Sato N, Tsuruoka N
Department of Internal Medicine, Tomakomai City Hospital, Japan.
Med Microbiol Immunol. 1989;178(6):337-46. doi: 10.1007/BF00197452.
The resistance in mice against Listeria infection was augmented by treatment with recombinant human tumor necrosis factor (TNF). To elucidate this phenomenon, we examined the effect of TNF on macrophage activation. TNF-treated macrophages had listericidal activity in vitro and superoxide anion production. In addition, macrophage migration was inhibited in the presence of TNF. Therefore, activation of macrophages by TNF was similar to activation by macrophage-activating factor or macrophage-migration-inhibitory factor.
用重组人肿瘤坏死因子（TNF）治疗可增强小鼠对李斯特菌感染的抵抗力。为阐明这一现象，我们研究了TNF对巨噬细胞激活的影响。经TNF处理的巨噬细胞在体外具有杀李斯特菌活性和超氧阴离子生成能力。此外，在TNF存在的情况下巨噬细胞迁移受到抑制。因此，TNF对巨噬细胞的激活类似于巨噬细胞激活因子或巨噬细胞迁移抑制因子所引起的激活。
