用索状因子以及热灭活和活卡介苗刺激巨噬细胞。
Stimulation of macrophages by cord factor and by heat-killed and living BCG.
作者信息
Yarkoni E, Wang L, Bekierkunst A
出版信息
Infect Immun. 1977 Apr;16(1):1-8. doi: 10.1128/iai.16.1.1-8.1977.
Abstract
Trehalose-6,6'-dimycolate (cord factor; CF) injected into the peritoneal cavity of mice induced stimulation of the peritoneal macrophages, evidenced both by increased activity of the lysosomal enzyme, acid phosphatase, and by increased phagocytosis of Listeria monocytogenes. The increase in enzyme activity and phagocytosis was similar to that induced by killed or living BCG. When administered intravenously, CF or BCG did not induce stimulation of peritoneal macrophages. CF when added to tissue cultures of normal peritoneal cells did not induce increased acid phosphatase activity or increased phagocytosis of L. monocytogenes.
摘要
将海藻糖-6,6'-二甲酯（索状因子；CF）注入小鼠腹腔可诱导腹膜巨噬细胞受到刺激，这可通过溶酶体酶酸性磷酸酶活性增加以及单核细胞增生李斯特菌吞噬作用增强得以证明。酶活性和吞噬作用的增加与灭活或活卡介苗诱导的情况相似。当静脉注射时，CF或卡介苗不会诱导腹膜巨噬细胞受到刺激。当将CF添加到正常腹膜细胞的组织培养物中时，不会诱导酸性磷酸酶活性增加或单核细胞增生李斯特菌吞噬作用增强。
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