Asbell P A, Centifanto-Fitzgerald Y M, Chandler J W, Kaufman H E
Invest Ophthalmol Vis Sci. 1984 Aug;25(8):951-4.
Isolates were obtained from 10 patients with recurrent herpes simplex type 1 infection of the eye, lids, or mouth. The viral DNA of successive isolates from each patients was analyzed by restriction endonuclease fingerprinting. Evaluation of the DNA banding patterns of all isolates by means of two different enzymes, performed in a masked fashion, demonstrated that all of the isolates from any one patient had the same genetic makeup. These results indicate that recurrent herpes infections of the eye and face in humans are caused not by unrelated, serial infections but rather by reactivation of the same latent virus that remains in the ganglion over a period of years.
从10例眼部、眼睑或口腔复发性单纯疱疹病毒1型感染患者中分离出病毒株。对每位患者连续分离出的病毒DNA进行限制性内切酶指纹分析。采用两种不同的酶，以盲法对所有分离株的DNA条带模式进行评估，结果表明，任一患者的所有分离株具有相同的基因组成。这些结果表明，人类眼部和面部的复发性疱疹感染不是由不相关的连续感染引起的，而是由多年来潜伏在神经节中的同一潜伏病毒重新激活所致。
