新型一次性平板透析器的评估以及再循环单程透析对清除率的不良影响。

Evaluation of a new disposable plate dialyzer and the adverse effect of recirculation single pass dialysis on clearance.

作者信息

Bierman M H, Easterling R E

出版信息

J Dial. 1977;1(7):653-64. doi: 10.3109/08860227709037661.

Abstract

A new disposable plate dialyzer (PF = Travenol Paraflo 1.0 m2 11.5 mu Cuprophan), is compared with an older device of similar design (GL = Gambro Lundia Nova 1.0 m2 13.5 mu Cuprophan). The ultrafiltration rate (UF) relative to dialyzer pressure (DP) was greater for GL (3.90 +/- .02 DP ml/min) than for this lot of PF (2.71 +/- .01 DP ml/min). In vivo clearance of urea and creatinine in single pass for PF was 132 +/- 5 ml/min and 106 +/- 5 ml/min, respectively, at mean blood rate of 200 ml/min. RSP produced significantly lower urea and creatinine clearance (p less than .005, less than .025). These values were not significantly different from those for GL. Decrease in patient BUN and plasma creatinine during dialysis corroborated the clearance data. SP operation of these plate dialyzers is recommended since the disadvantages of RSP outweigh its advantages.

摘要

将一种新型一次性平板透析器（PF = Travenol Paraflo，膜面积1.0平方米，超滤系数11.5ml/(mmHg·h)，铜仿膜）与一种设计类似的旧款透析器（GL = Gambro Lundia Nova，膜面积1.0平方米，超滤系数13.5ml/(mmHg·h)，铜仿膜）进行比较。相对于透析器压力（DP）的超滤率（UF），GL（3.90±0.02 DP ml/min）高于该批次的PF（2.71±0.01 DP ml/min）。在平均血流速度为200 ml/min时，PF单次通过时尿素和肌酐的体内清除率分别为132±5 ml/min和106±5 ml/min。逆超滤液（RSP）产生的尿素和肌酐清除率显著更低（p＜0.005，＜0.025）。这些值与GL的值无显著差异。透析期间患者血尿素氮（BUN）和血浆肌酐的下降证实了清除率数据。由于逆超滤液（RSP）的缺点超过其优点，因此建议使用这些平板透析器进行顺超（SP）操作。