神经系统疾病的DNA标记物。
DNA markers for nervous system diseases.
作者信息
Gusella J F, Tanzi R E, Anderson M A, Hobbs W, Gibbons K, Raschtchian R, Gilliam T C, Wallace M R, Wexler N S, Conneally P M
出版信息
Science. 1984 Sep 21;225(4668):1320-6. doi: 10.1126/science.6089346.
Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.
重组DNA技术提供了大量新的DNA标记来源，这些标记在人类中呈现出可遗传的序列变异。这些标记可用于家族研究，以确定导致神经系统疾病的缺陷基因在染色体上的位置。与亨廷顿舞蹈病相关的DNA标记的发现为对该疾病的研究开辟了新途径，并最终可能使缺陷基因得以克隆和鉴定。
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