Namiki M, Koide T, Okuyama A, Sonoda T, Itatani H, Miyake A, Aono T, Terada N, Matsumoto K
Acta Endocrinol (Copenh). 1984 Aug;106(4):548-55. doi: 10.1530/acta.0.1060548.
To ascertain whether abnormalities in testicular binding of follicle stimulating hormone (FSH) are related with spermatogenic impairment found in idiopathic male infertility, we measured FSH receptors in testicular tissues obtained by biopsy from 37 infertile men. Since there had been few reports on the characterization of human testicular FSH receptor, we first established conditions for FSH receptor assay in small amounts of human testicular tissues taken by biopsy. Thirty-seven infertile men were divided into 3 groups by histological grading using Johnsen's score count, and testicular FSH receptors among these groups were compared. Although 6 of 12 infertile men with low Johnsen's score count and 3 of 9 men with middle score count had no obvious FSH binding sites with high affinity, all 16 men with high score count had high affinity FSH binding sites. The present findings demonstrate that the decrease in testicular high affinity binding sites for FSH is related with the degree of spermatogenic impairment found in idiopathic male infertility.
为确定卵泡刺激素（FSH）的睾丸结合异常是否与特发性男性不育症中的生精障碍相关，我们检测了37名不育男性活检获取的睾丸组织中的FSH受体。由于关于人类睾丸FSH受体特征的报道较少，我们首先建立了活检获取的少量人类睾丸组织中FSH受体检测方法。采用约翰森评分计数法对37名不育男性进行组织学分级并分为3组，比较各组间的睾丸FSH受体。约翰森评分低的12名不育男性中有6名，评分中等的9名男性中有3名没有明显的高亲和力FSH结合位点，而所有16名评分高的男性均有高亲和力FSH结合位点。目前的研究结果表明，睾丸中FSH高亲和力结合位点的减少与特发性男性不育症中的生精障碍程度相关。
