Namiki M, Nakamura M, Okuyama A, Sonoda T, Doi Y, Matsui T, Fujisue H, Takeyama M, Fujioka H, Hayashi T
Department of Urology, Osaka University Medical School.
Hinyokika Kiyo. 1988 Jun;34(6):951-5.
To ascertain whether abnormalities in testicular binding of follicle-stimulating hormone (FSH) are related with spermatogenic impairment found in idiopathic male infertility, we measured FSH receptors in testicular tissues obtained by biopsy from 48 infertile men. The 48 infertile men were divided into 3 groups by histological grading using Johnsen's score count, and testicular FSH receptors among these groups were compared. Although 9 of the 18 infertile men with low Johnsen's score count and 5 of the 15 men with middle score count had no obvious FSH binding sites with high affinity, all 15 men with a high score count had high affinity FSH binding sites. In connection with high affinity binding sites for FSH, maximum binding number (Bmax) decreased significantly with the degree of spermatogenic impairment, but the association constant (Ka) was similar among the 3 groups. The present findings demonstrate that the decrease in testicular high affinity binding sites for FSH is related with the degree of spermatogenic impairment found in idiopathic male infertility.
为了确定卵泡刺激素（FSH）的睾丸结合异常是否与特发性男性不育症中发现的生精障碍有关，我们检测了48名不育男性活检获得的睾丸组织中的FSH受体。根据约翰森评分计数的组织学分级，将这48名不育男性分为3组，并比较了这些组之间的睾丸FSH受体。虽然18名约翰森评分低的不育男性中有9名和15名评分中等的男性中有5名没有明显的高亲和力FSH结合位点，但所有15名评分高的男性都有高亲和力FSH结合位点。关于FSH的高亲和力结合位点，最大结合数（Bmax）随着生精障碍程度的增加而显著降低，但3组之间的结合常数（Ka）相似。目前的研究结果表明，睾丸中FSH高亲和力结合位点的减少与特发性男性不育症中发现的生精障碍程度有关。
