间断性阿昔洛韦治疗对潜伏感染三叉神经节中单纯疱疹病毒体外再激活的影响。
Effect of discontinuous acyclovir treatment on in vitro reactivation of herpes simplex virus from latently infected trigeminal ganglia.
作者信息
Klein R J, Friedman-Kien A E, DeStefano E
出版信息
Antimicrob Agents Chemother. 1983 Jul;24(1):129-31. doi: 10.1128/AAC.24.1.129.
Abstract
Exposing explant cultures of latently infected mouse trigeminal ganglia alternately to acyclovir-containing and drug-free medium led to a significant decrease in the proportion of ganglia containing reactivatable herpes simplex virus. The loss of virus from the explant cultures was not caused by thermal inactivation during prolonged incubation periods. The efficiency of virus elimination may depend on the frequency and duration of the alternating treatment and on the number of latently infected neurons in the ganglia.
摘要
将潜伏感染的小鼠三叉神经节的外植体培养物交替置于含阿昔洛韦的培养基和无药物培养基中，导致含有可重新激活的单纯疱疹病毒的神经节比例显著下降。外植体培养物中病毒的损失并非由长时间孵育期间的热灭活引起。病毒清除效率可能取决于交替处理的频率和持续时间以及神经节中潜伏感染神经元的数量。
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