1-β-D-阿拉伯呋喃糖基-E-5-(2-溴乙烯基)尿嘧啶（BV-araU）及相关化合物的体外和体内抗病毒活性
In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds.
作者信息
Machida H, Sakata S
出版信息
Antiviral Res. 1984 Jun;4(3):135-41. doi: 10.1016/0166-3542(84)90013-5.
PMID:6089657
Abstract
BV-araU and related compounds such as CV-araU, IV-araU and BV-araUMP showed marked activity against herpes simplex virus type 1 (HSV-1) in human embryonic lung fibroblast cells. BV-araU, CV-araU and BV-araUMP were also effective in mice infected intracerebrally with HSV-1. Especially, when mice were infected with a low dose of virus, both intravenous and oral treatment with BV-araU proved capable of increasing the mean survival time and decreasing the final mortality of the infected mice. The in vivo anti-HSV-1 activity of BV-araU was comparable to that of BVDU. BV-araU exhibited little toxicity for mice.
摘要
BV-araU以及相关化合物，如CV-araU、IV-araU和BV-araUMP，在人胚肺成纤维细胞中对单纯疱疹病毒1型（HSV-1）显示出显著活性。BV-araU、CV-araU和BV-araUMP对脑内感染HSV-1的小鼠也有效。特别是，当小鼠感染低剂量病毒时，BV-araU的静脉注射和口服治疗均能延长感染小鼠的平均存活时间并降低最终死亡率。BV-araU的体内抗HSV-1活性与BVDU相当。BV-araU对小鼠的毒性很小。
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