Ravid A, Koren R, Novogrodsky A, Liberman U A
Biochem Biophys Res Commun. 1984 Aug 30;123(1):163-9. doi: 10.1016/0006-291x(84)90394-2.
Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physiological concentrations, inhibits the mitogenic response of the medullary cells to phytohemagglutinin and interleukin-2, but has no effect on the cortical subpopulation. Other less active metabolites of vitamin D had little or no effect on medullary cell stimulation.
通过用花生凝集素进行差异凝集，将小鼠胸腺细胞分离为皮质和髓质亚群。1,25 - 二羟基维生素D3的高亲和力受体存在于髓质免疫活性小鼠胸腺细胞中，而皮质未成熟细胞中则不存在。生理浓度的1,25 - 二羟基维生素D3可抑制髓质细胞对植物血凝素和白细胞介素 - 2的促有丝分裂反应，但对皮质亚群没有影响。维生素D的其他活性较低的代谢产物对髓质细胞刺激作用很小或没有作用。
