Amato D, Fernandes B J, Klein M
Can Med Assoc J. 1984 Sep 15;131(6):595-600.
A black, West Indian woman with adult T-cell leukemia-lymphoma (ATLL), hypercalcemia, peripheral and retroperitoneal lymphadenopathy, and serum antibodies to human T-lymphotropic virus (HTLV) was found to have massive mediastinal adenopathy, a feature not previously reported in patients with ATLL. In addition, she had had asymptomatic leukocytosis with marked lymphocytosis for at least 6 years before presenting with full-blown ATLL. These findings broaden the clinical picture of ATLL. Cell surface-marker studies and close follow-up are recommended for patients with apparent chronic lymphocytic leukemia, especially if they have pleomorphic lymphocytosis, are younger than usual or are from the Caribbean or Japan.
一名患有成人T细胞白血病淋巴瘤（ATLL）、高钙血症、外周和腹膜后淋巴结病且血清中有人T细胞嗜淋巴细胞病毒（HTLV）抗体的西印度黑人女性，被发现有巨大纵隔淋巴结病，这是ATLL患者此前未曾报道过的特征。此外，在出现典型的ATLL之前，她至少有6年的无症状白细胞增多伴明显淋巴细胞增多。这些发现拓宽了ATLL的临床症状。对于明显患有慢性淋巴细胞白血病的患者，尤其是那些有多形性淋巴细胞增多、年龄比一般患者小或者来自加勒比地区或日本的患者，建议进行细胞表面标志物研究并密切随访。
