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相似文献

1
Genesis of Kirsten murine sarcoma virus: sequence analysis reveals recombination points and potential leukaemogenic determinant on parental leukaemia virus genome.Kirsten小鼠肉瘤病毒的起源：序列分析揭示了亲本白血病病毒基因组上的重组点和潜在的白血病致病决定因素。
Nucleic Acids Res. 1984 Sep 11;12(17):6839-52. doi: 10.1093/nar/12.17.6839.
2
Sequence relationships between Kirsten retrovirus genomes and the genomes of other murine retroviruses.柯斯顿逆转录病毒基因组与其他鼠类逆转录病毒基因组之间的序列关系。
Virology. 1983 Apr 15;126(1):126-54. doi: 10.1016/0042-6822(83)90467-1.
3
Structure and functions of the Kirsten murine sarcoma virus genome: molecular cloning of biologically active Kirsten murine sarcoma virus DNA.柯斯顿鼠肉瘤病毒基因组的结构与功能：具有生物活性的柯斯顿鼠肉瘤病毒DNA的分子克隆
J Virol. 1981 May;38(2):720-7. doi: 10.1128/JVI.38.2.720-727.1981.
4
Characterization and cloning of the Kirsten murine leukemia virus genome.克尔斯滕小鼠白血病病毒基因组的表征与克隆
Biochem Biophys Res Commun. 1984 Feb 29;119(1):150-6. doi: 10.1016/0006-291x(84)91631-0.
5
Heteroduplex analysis of the sequence relationships between the genomes of Kirsten and Harvey sarcoma viruses, their respective parental murine leukemia viruses, and the rat endogenous 30S RNA.对柯斯顿肉瘤病毒和哈维肉瘤病毒基因组、它们各自的亲代鼠白血病病毒以及大鼠内源性30S RNA之间序列关系的异源双链分析。
J Virol. 1979 Sep;31(3):752-60. doi: 10.1128/JVI.31.3.752-760.1979.
6
Genetic organization and cloning of Kirsten murine sarcoma virus DNA.柯斯顿鼠肉瘤病毒DNA的基因组织与克隆
Biochem Biophys Res Commun. 1982 Oct 29;108(4):1631-7. doi: 10.1016/s0006-291x(82)80096-x.
7
The virion RNA species of the Kirsten murine sarcoma-leukemia virus complex released from a clonally related series of mouse cells.从一系列克隆相关的小鼠细胞中释放出的 Kirsten 小鼠肉瘤 - 白血病病毒复合体的病毒粒子 RNA 种类。
Arch Virol. 1982;72(1-2):35-46. doi: 10.1007/BF01314448.
8
Apparent recombinants between virus-liKE (VL30) and murine leukemia virus-related sequences in mouse DNA.小鼠DNA中病毒样（VL30）序列与鼠白血病病毒相关序列之间的明显重组体。
J Virol. 1983 Jul;47(1):178-84. doi: 10.1128/JVI.47.1.178-184.1983.
9
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.编码柯斯顿鼠肉瘤病毒p21转化蛋白的癌基因的核苷酸序列。
Science. 1982 Sep 3;217(4563):937-9. doi: 10.1126/science.6287573.
10
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.恶性组织细胞增多症肉瘤病毒，是哈维鼠肉瘤病毒和弗瑞德貂细胞集落形成病毒的重组体，通过长末端重复序列的改变获得了髓系转化特异性。
J Virol. 1990 Jan;64(1):369-78. doi: 10.1128/JVI.64.1.369-378.1990.

引用本文的文献

1
A perspective on the early days of RAS research.RAS 研究早期的思考。
Cancer Metastasis Rev. 2020 Dec;39(4):1023-1028. doi: 10.1007/s10555-020-09919-1. Epub 2020 Jul 29.
2
Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene.莫洛尼鼠白血病病毒-病毒样30重组体的结构：对c-Ha-ras原癌基因转导的影响
J Virol. 1993 Mar;67(3):1286-91. doi: 10.1128/JVI.67.3.1286-1291.1993.
3
Analysis of ras genes and linked viral sequences in rat hepatocarcinogenesis.大鼠肝癌发生过程中ras基因及相关病毒序列的分析。
Am J Pathol. 1987 Nov;129(2):232-41.
4
Kirsten murine sarcoma virus abolishes interferon gamma-induced class II but not class I major histocompatibility antigen expression in a murine fibroblast line.柯斯顿鼠肉瘤病毒可消除鼠成纤维细胞系中γ干扰素诱导的Ⅱ类主要组织相容性抗原表达，但不影响Ⅰ类主要组织相容性抗原表达。
J Exp Med. 1988 Feb 1;167(2):706-11. doi: 10.1084/jem.167.2.706.
5
Regulation of IFN-gamma-induced host cell MHC antigen expression by Kirsten MSV and MLV. II. Effects on class II antigen expression.克尔斯滕小鼠肉瘤病毒和小鼠白血病病毒对干扰素-γ诱导的宿主细胞MHC抗原表达的调节。II. 对II类抗原表达的影响。
Immunology. 1989 May;67(1):26-31.
6
Regulation of IFN-gamma-induced host cell MHC antigen expression by Kirsten MSV and MLV. I. Effects on class I antigen expression.柯斯顿小鼠肉瘤病毒和小鼠白血病病毒对干扰素γ诱导的宿主细胞主要组织相容性复合体抗原表达的调节。I. 对I类抗原表达的影响。
Immunology. 1989 May;67(1):21-5.
7
Instability of expression of major histocompatibility antigens in fibroblasts expressing activated ras oncogene: constitutive and interferon-gamma induced class I and class II antigens in a series of clonal isolates of murine fibroblasts transformed by v-Ki-ras.表达活化的ras癌基因的成纤维细胞中主要组织相容性抗原表达的不稳定性：在一系列经v-Ki-ras转化的小鼠成纤维细胞克隆分离株中组成性及干扰素-γ诱导的I类和II类抗原
Br J Cancer. 1989 Aug;60(2):211-5. doi: 10.1038/bjc.1989.253.
8
Independent regulation of mouse VL30 retrotransposon expression in response to serum and oncogenic cell transformation.小鼠VL30逆转录转座子表达对血清和致癌细胞转化的独立调控。
Nucleic Acids Res. 1990 Apr 25;18(8):2069-77. doi: 10.1093/nar/18.8.2069.
9
Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design.哺乳动物C型病毒U3区域序列的比对：高度保守基序的鉴定及其对增强子设计的意义
J Virol. 1990 Feb;64(2):534-42. doi: 10.1128/JVI.64.2.534-542.1990.
10
Inducibility of class II major histocompatibility complex antigens by interferon gamma is associated with reduced tumorigenicity in C3H mouse fibroblasts transformed by v-Ki-ras.γ干扰素对II类主要组织相容性复合体抗原的诱导作用与v-Ki-ras转化的C3H小鼠成纤维细胞的致瘤性降低有关。
J Exp Med. 1991 Jan 1;173(1):193-6. doi: 10.1084/jem.173.1.193.

本文引用的文献

1
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication.人类α-珠蛋白假基因的结构及其与α-珠蛋白基因重复的关系。
Cell. 1980 Sep;21(2):537-44. doi: 10.1016/0092-8674(80)90491-2.
2
Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination.通过明显的非法重组产生新型生物活性哈维肉瘤病毒。
J Virol. 1981 Apr;38(1):136-50. doi: 10.1128/JVI.38.1.136-150.1981.
3
Facile transition of poly[d(TG) x d(CA)] into a left-handed helix in physiological conditions.在生理条件下，聚[d(TG)x d(CA)]能轻松转变为左手螺旋。
Nature. 1983 Apr 14;302(5909):632-4. doi: 10.1038/302632a0.
4
A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.一种具有形成Z-DNA潜力的新型重复元件广泛存在于进化上多样的真核生物基因组中。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6465-9. doi: 10.1073/pnas.79.21.6465.
5
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus.莫洛尼鼠肉瘤病毒长末端重复序列中增强子元件的特性分析。
J Virol. 1984 Jan;49(1):183-9. doi: 10.1128/JVI.49.1.183-189.1984.
6
The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.序列（dC-dA）n×（dG-dT）n在负超螺旋质粒中形成左手Z-DNA。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1821-5. doi: 10.1073/pnas.80.7.1821.
7
Unusual long terminal repeat sequence of a retrovirus transmissible mouse (VL 30) genetic element: identification of functional domains.一种可传播的逆转录病毒小鼠（VL 30）遗传元件的异常长末端重复序列：功能域的鉴定
Nucleic Acids Res. 1984 Apr 25;12(8):3445-60. doi: 10.1093/nar/12.8.3445.
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A new package for an old oncogene.旧癌基因的新包裹。
Nature. 1984;308(5962):775. doi: 10.1038/308775a0.
9
Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat.通过长末端重复序列内的序列测定鼠逆转录病毒的致白血病性。
Nature. 1984;308(5958):467-70. doi: 10.1038/308467a0.
10
Characterization and cloning of the Kirsten murine leukemia virus genome.克尔斯滕小鼠白血病病毒基因组的表征与克隆
Biochem Biophys Res Commun. 1984 Feb 29;119(1):150-6. doi: 10.1016/0006-291x(84)91631-0.

Kirsten小鼠肉瘤病毒的起源：序列分析揭示了亲本白血病病毒基因组上的重组点和潜在的白血病致病决定因素。

Genesis of Kirsten murine sarcoma virus: sequence analysis reveals recombination points and potential leukaemogenic determinant on parental leukaemia virus genome.

作者信息

Norton J D, Connor J, Avery R J

出版信息

Nucleic Acids Res. 1984 Sep 11;12(17):6839-52. doi: 10.1093/nar/12.17.6839.

DOI:10.1093/nar/12.17.6839
PMID:6091040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320120/
Abstract

The genome of Kirsten murine sarcoma virus was formed by recombination between Kirsten murine leukaemia virus sequences, and rat sequences derived from a retrovirus-like '30S' (VL30) genetic element encompassing the Kras oncogene. Using cloned DNAs we have determined the nucleotide sequences of the long terminal repeats and adjacent regions, extending across the points of recombination on the sarcoma and leukaemia virus genomes. Our results suggest that discrete regions of homology and other cryptic sequence features, may have constituted recombinational hot-spots involved in the genesis of the Kirsten murine sarcoma virus genome. We have also compared the sequence of the Kirsten murine leukaemia virus p15 env and adjacent long terminal repeat with the corresponding regions of the AKV and Gross A murine leukaemia virus genomes. This comparison has identified a leukaemogenic determinant in the U3 domain of the long terminal repeat, possibly within a enhancer-like sequence element.

摘要

柯斯顿鼠肉瘤病毒的基因组是由柯斯顿鼠白血病病毒序列与源自包含Kras癌基因的逆转录病毒样“30S”（VL30）遗传元件的大鼠序列之间的重组形成的。利用克隆的DNA，我们确定了长末端重复序列及其相邻区域的核苷酸序列，这些区域跨越了肉瘤病毒和白血病病毒基因组上的重组点。我们的结果表明，离散的同源区域和其他隐蔽的序列特征，可能构成了参与柯斯顿鼠肉瘤病毒基因组起源的重组热点。我们还将柯斯顿鼠白血病病毒p15 env和相邻的长末端重复序列的序列与AKV和格罗斯A鼠白血病病毒基因组的相应区域进行了比较。这种比较在长末端重复序列的U3结构域中确定了一个白血病致病决定因素，可能在一个类似增强子的序列元件内。